• J. Neurol. Neurosurg. Psychiatr. · Aug 1973

    Creutzfeldt-Jakob disease treated with amantidine. A report of two cases.

    • W L Sanders and T L Dunn.
    • J. Neurol. Neurosurg. Psychiatr. 1973 Aug 1;36(4):581-4.

    AbstractThe treatment of two cases of Creutzfeldt-Jakob disease with amantidine is described. The first case made a remarkable initial improvement which was sustained for two months, but then deteriorated and died. Histological examination of the brain showed changes consistent with early Creutzfeldt-Jakob disease. The second case which was clinically one of Creutzfeldt-Jakob disease has now been followed for 30 months since the start of treatment and appears to be cured. It is considered that amantidine has a definite effect in this disease and it is suggested that its mode of action, though unknown, is more likely to be metabolic than antiviral.

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