• Peng Yin, Yongjun Fan, Wensheng Dong, Shike Shao, Jiaqiu Zhu, Xianlong Zhu, and Hui Shi.
• Department of Neurosurgery, Lianyungang Second People's Hospital, Bengbu Medical College, Jiangsu, China.
• World Neurosurg. 2023 Aug 1; 176: e1e7e1-e7.

PurposeTo investigate the value of CD64 in the early diagnosis of intracranial infection after craniocerebral surgery.MethodsA total of 93 patients who met the inclusion and exclusion criteria after neurosurgery in Lianyungang First People's Hospital and Lianyungang Second People's Hospital were admitted and divided into experimental group with intracranial infection (n = 32) and uninfected control group (n = 61) according to the results of cerebrospinal fluid culture. We performed relevant statistical analysis, drew the receiver operating characteristic curve and calculated area under the curve (AUC).ResultsThe sensitivity and specificity of the CD64, c-reactive protein (CRP), and white blood cell (WBC) counts were 84.38% and 86.89%, 78.13% and 75.41%, and 75.00% and 67.21%, respectively; the AUCs were 0.912, 0.858, and 0.851, respectively. Accuracy was the highest when the 3 diagnosis were combined, reaching 93.75%; the AUC could reach 0.948.ConclusionsSerum CD64, CRP, and WBC count in the diagnosis of intracranial infection after craniocerebral surgery were significant. CD64 was more valuable than the others. The diagnostic efficiency could be improved when CD64, CRP, and WBC count were combined.Copyright © 2022. Published by Elsevier Inc.

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