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Case Reports
Reversible Brain Atrophy in Cryptogenic New-onset Refractory Status Epilepticus: A Case Report.
- Tomoaki Watanabe, Masahiro Nakamori, Kenichi Ishikawa, Atsuko Motoda, Shuichiro Neshige, Shotaro Yamamoto, Kento Katahira, Toru Higaki, Hiroki Ueno, Takahiro Iizuka, and Hirofumi Maruyama.
- Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan.
- Intern. Med. 2023 Jun 15; 62 (12): 183518421835-1842.
AbstractCryptogenic new-onset refractory status epilepticus (C-NORSE) is a neurologic emergency condition characterized by refractory status epilepticus (RSE) of unknown cause. Brain atrophy in a setting of C-NORSE is usually irreversible. A 33-year-old woman who was highly suspected of C-NORSE once showed mild frontotemporal atrophy on brain magnetic resonance imaging (MRI), but follow-up MRI revealed recovery of the brain atrophy. Her cognitive function also gradually improved, with a reduction in seizure frequency. Early initiation of intensive immunotherapy with anti-seizure medications may have minimized irreversible brain damage associated with RSE, resulting in a relatively good outcome.
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