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- Masashi Yokoi, Tsuyoshi Ito, Junki Yamamoto, Kento Mori, Kosuke Nakasuka, Hiroshi Fujita, Shuichi Kitada, Toshihiko Goto, and Yoshihiro Seo.
- Department of Cardiology, Nagoya City University Graduate School of Medical Sciences, Japan.
- Intern. Med. 2023 Jun 15; 62 (12): 178517881785-1788.
AbstractA 75-year-old man receiving treatment for necrotizing pancreatitis developed septic disseminated intravascular coagulation and acute coronary syndrome (ACS). During percutaneous coronary intervention (PCI), a large amount of fresh thrombi appeared after balloon dilatation for the ACS-culprit lesion. Given the low plasma antithrombin (AT) activity and poorly prolonged activated clotting time (ACT), we suspected that acquired AT deficiency-related heparin resistance (HR) was responsible for the thrombus formation. Administration of AT gamma markedly improved ACT, and we successfully completed PCI. We suggest that AT gamma be considered a treatment option for AT deficiency-related HR and subsequent intraprocedural thrombotic events.
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