• Laryngo- rhino- otologie · Nov 2007

    Review

    [ACE-inhibitor induced angioedema].

    • M Bas, T K Hoffmann, G Kojda, and H Bier.
    • Hals-Nasen-Ohrenklinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, München, Germany. basmurat@web.de
    • Laryngorhinootologie. 2007 Nov 1;86(11):804-8, quiz 809-13.

    AbstractACE-inhibitor induced angioedema is a non-allergic drug-related side effect. Inhibited bradykinin degradation leads to an unphysiological enhanced bradykinin plasma level with vascular leakage and, consequently, to angioedema. ACE-inhibitor induced angioedema develop rapidly in the head and neck region. Typical sites of manifestation are lips, tongue, and larynx. Novel pharmacotherapies may allow a causal treatment of the ACE-inhibitor induced angioedema in the future.

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