• Olgu Erkin Çınar, Batuhan Erdoğdu, Mine Karadeniz, Sercan Ünal, Ümit Yavuz Malkan, Hakan Göker, and İbrahim Celalettin Haznedaroğlu.
• Division of Hematology, Department of Internal Medicine, Hacettepe University, 06800 Ankara, Turkey.
• Medicina (Kaunas). 2022 Nov 1; 58 (11).

AbstractThe SARS-CoV-2 spike protein mRNA-based vaccines have prevented countless mortality and morbidity, and have an excellent risk/benefit ratio. However, various adverse events may rarely occur after the BNT162b2 vaccine, like any other medical intervention. The COVID-19 itself and the spike protein produced endogenously by mRNA vaccines may have immunological, microenvironmental, prothrombotic, and neoplastic effects. As a contribution to the published report, we would like to share our experience regarding four cases in which myeloid neoplasms emerged following the vaccination. Conclusions: There is no doubt that vaccination could continue along the lines of established universal recommendations. Meanwhile, all hematological adverse events must be closely monitored and reported. Further efforts should be focused on the probable pathobiological mechanisms and causalities of spike protein-related toxicity and clonal myeloid disorders.

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