• Venkatesh S Madhugiri, Subeikshanan Venkatesan, Akshat Dutt, Aliasgar V Moiyadi, Prakash Shetty, Tejpal Gupta, Sridhar Epari, Rakesh Jalali, Gopalakrishnan M Sasidharan, KumarV R RoopeshVRRDepartment of Surgical Oncology, Apollo Proton Cancer Centre, Chennai, India., GaneshC V ShankarCVSDepartment of Neurosurgery, Apollo Hospitals, Chennai, India., Andi Sadayandi Ramesh, A Sathia Prabhu, and Anil Kumar Dutt.
• Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India. Electronic address: venkatesh@nimhans.ac.in.
• World Neurosurg. 2023 Feb 1; 170: e292e300e292-e300.

BackgroundGlioblastoma (GBM) is the most frequently diagnosed malignant brain tumor in adults. GBM is usually lethal within 24 months of diagnosis, despite aggressive multimodality treatment. Although it has been established that cancer-related inflammation is associated with worse outcomes, the role of eosinophils, basophils, atopy, and allergy in glioma biology is only gradually being delineated. In this study, we aimed to examine if eosinophil-based and basophil-based indices were altered in patients with GBM compared with healthy controls. We also aimed to study if there was any correlation between these indices and patient-related and tumor-related factors and survival.MethodsThis study was a retrospective analysis of prospectively maintained databases. Data pertaining to patient-related and tumor-related factors, hemograms, and survival data were obtained from the electronic medical records of selected patients. Correlations between eosinophil-based and basophil-based indices and these factors were studied, as was the association with overall survival.ResultsAll the indices were altered in patients with GBM compared with normal healthy controls. The absolute eosinophil count was higher and the neutrophils/eosinophils ratio was lower in the better prognosis groups: those with better performance status; those without features of increased intracranial pressure or altered sensorium at presentation; those with ATRX-retained tumors that did not overexpress p53; and in the long-term survivors. The total lymphocyte count/basophils ratio and the absolute eosinophil count both independently predicted survival in a multivariate analysis.ConclusionsThe absolute eosinophil count was consistently higher in the better prognosis groups and is likely to be incorporated into prognostic models for GBM.Copyright © 2022 Elsevier Inc. All rights reserved.

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