• Kaitlin Demarest, Harish Lavu, Elizabeth Collins, and Vivek Batra.
• Kaitlin Demarest, MD, is with, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA; Harish Lavu, MD, is with the Department of Surgery, Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA; Elizabeth Collins, MD, is with the Department of Family & Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA; Vivek Batra, MD, is with the Department of Medical Oncology, Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
• J Pain Palliat Care Pharmacother. 2023 Mar 1; 37 (1): 9110591-105.

AbstractMalignant bowel obstruction is a common complication of advanced gastrointestinal, gynecologic, and genitourinary tumors. Patients present with nausea, vomiting, abdominal pain, and constipation. Cross-sectional imaging is essential to make a diagnosis of bowel obstruction. Initial management is conservative with fluid replacement, electrolyte replacement, bowel rest and sometimes nasogastric decompression. Numerous advanced options exist for definitive management, though none are overly promising but nevertheless may improve quality and quantity of life. Surgical bypass, endoscopic stenting, and endoscopic decompression are some of the options with variable efficacy and are employed in select patients. Chemotherapy may be utilized if the bowel obstruction resolves to reduce tumor burden in a limited number of patients. Parenteral nutrition is an option and should typically be used in surgical patients with good functional and nutritional status with limited tumor burden or curative intent. Palliative care and hospice should be discussed in patients with advanced malignancy who present with peritoneal carcinomatosis or multiple levels of obstruction. Overall prognosis of malignant bowel obstruction is poor, and median survival ranges from 26 to 192 days.

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