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Journal of neurotrauma · May 2023
ReviewSpecies Differences in Blood Lymphocyte Responses After Spinal Cord Injury.
- Carlos Ayala, Morgan Fishman, Margot Noyelle, Hamid Bassiri, and Wise Young.
- W.M. Keck Center for Collaborative Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.
- J. Neurotrauma. 2023 May 1; 40 (9-10): 807819807-819.
AbstractPeople with spinal cord injury (SCI) get recurrent infections, such as urinary tract infections (UTIs) and pneumonias, that cause mortality and worsen neurological recovery. Over the past decades, researchers have proposed that post-SCI lymphopenia and decreased lymphocyte function increase susceptibility to infections and worsen neurological outcome in humans, leading to a condition called SCI-induced immune depression syndrome (SCI-IDS). In this review, we explore how SCI affects blood lymphocyte homeostasis and function in humans and rodents. Understanding how SCI affects blood lymphocytes will help the management of recurrent infections in spinal cord injured people and shed light on the clinical translation of findings in animal models to humans.
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