• Guanghui Zhou, Kan Liu, Xiuhai Ji, Yan Fen, Yinjie Gu, and Hui Ding.
• Department of Pulmonary & Critical Care Medicine, The Affiliated Yixing People's Hospital of Jiangsu University, Yixing, China.
• Clinics (Sao Paulo). 2022 Jan 1; 77: 100133100133.

ObjectiveThe aim is to evaluate the diagnostic value of Activin A levels in serum and pleural fluid on Parapneumonic Pleural Effusion (PPE).MethodsThe authors collected serum and pleural fluid from 86 PPE and 37 Non-PPE (NPPE) patients. Including Activin A, levels of biomarkers such as Lactate Dehydrogenase (LDH), Procalcitonin (PCT), and C-Reactive Protein (CRP) were measured. All factors were calculated for association with days after admission. The diagnostic potential of biomarkers on PPE was considered by Receiver Operating Characteristic (ROC) curve analysis.ResultsLevels of Activin A in serum and pleural fluid of PPE patients were significantly higher than those of the NPPE patients. Moreover, concentrations of Activin A in pleural fluid showed a more obvious relevant days after admission. ROC curve analysis found that Activin A in pleural fluid had AUCs of 0.899 with 93% sensitivity and 84% specificity for PPE diagnosis.ConclusionActivin A in pleural fluid correlated with disease severity could act to diagnose PPE.Copyright © 2022 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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