• Şerban-Ion Bubenek-Turconi, Stefan Andrei, Liana Văleanu, Mihai-Gabriel Ştefan, Ioana Grigoraş, Sanda Copotoiu, Constantin Bodolea, Dana Tomescu, Mihai Popescu, Daniela Filipescu, Horatiu Moldovan, Alexandru-Florin Rogobete, Cosmin Bălan, Bianca Moroşanu, Dorel Săndesc, Raed Arafat, and COVATI-RO Collaborative .
• From the Anesthesiology and Intensive Care Department, Carol Davila University of Medicine and Pharmacy (Ş-IB-T, SA, DT, MP, DF, BM), Cardiac Anesthesiology and Intensive Care Department I, Emergency Institute for Cardiovascular Diseases Prof. Dr C. C. Iliescu, Bucharest, Romania (Ş-IB-T, LV, CB, BM), Anaesthesiology and Critical Care Department, Dijon Bourgogne University Hospital, Dijon, France (SA), Cardiac Anesthesiology and Intensive Care Department II, Emergency Institute for Cardiovascular Diseases Prof. Dr C. C. Iliescu, Bucharest, Romania (M-GŞ, DF), Anaesthesiology and Intensive Care Department, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania (IG), Anaesthesiology and Intensive Care Department, Regional Institute of Oncology, Iaşi, Romania (IG), Anaesthesiology and Intensive Care Department, George Emil Palade University of Medicine, Pharmacy, Science, and Technology, Târgu Mureş, Romania (SC), Anaesthesiology and Intensive Care Department II, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca (CB), Anaesthesiology and Intensive Care Department III, Fundeni Clinical Institute (DT, MP), Department of Cardiovascular Surgery, Clinical Emergency Hospital Bucharest, 014461, Bucharest, Romania; Department of Cardiovascular Surgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania (HM), Anaesthesiology and Intensive Care Department, Emergency County Hospital Pius Brinzeu (FR, DS), Anaesthesiology and Intensive Care Department, Victor Babeş University of Medicine and Pharmacy, Timişoara (FR, DS) and Department for Emergency Situations, Ministry of Internal Affairs, Bucharest, Romania (RA).
• Eur J Anaesthesiol. 2023 Jan 1; 40 (1): 4124-12.

BackgroundThe epidemiology of critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be different worldwide. Despite similarities in medicine quality and formation, there are also significant differences concerning healthcare and ICU organisation, staffing, financial resources and population compliance and adherence. Large cohort data of critically ill patients from Central and Eastern Europe are also lacking.ObjectivesThe study objectives were to describe the clinical characteristics of patients admitted to Romanian ICUs with SARS-CoV-2 infection and to identify the factors associated with ICU mortality.DesignProspective, cohort, observational study.SettingNational recruitment, multicentre study, between March 2020 to March 2021.PatientsAll patients with SARS-CoV-2 infection admitted to Romanian ICUs were eligible. There were no exclusion criteria.InterventionNone.Main Outcome MeasureICU mortality.ResultsThe statistical analysis included 9058 patients with definitive ICU outcome. The multivariable mixed effects logistic regression model found that age [odds ratio (OR) 1.27; 95% confidence interval (CI), 1.23 to 1.31], male gender (OR 1.21; 95% CI 1.05 to 1.4), medical history of neoplasia (OR 1.74; 95% CI, 1.36 to 2.22), chronic kidney disease (OR 1.54; 95% CI, 1.27 to 1.88), type II diabetes (OR 1.23; 95% CI, 1.06 to 1.43), chronic heart failure (OR 1.24; 95% CI, 1.03 to 1.49), dyspnoea (OR 1.3; 95% CI, 1.1 to 1.5), SpO2 less than 90% (OR 3; 95% CI, 2.5 to 3.5), admission SOFA score (OR 1.07; 95% CI, 1.05 to 1.09), acute respiratory distress syndrome (ARDS) on ICU admission (OR 1.35; 95% CI, 1.1 to 1.63) and the need for noninvasive (OR 1.8, 95% CI, 1.5 to 1.22) or invasive ventilation (OR 28; 95% CI, 22 to 35) and neuromuscular blockade (OR 3.5; 95% CI, 2.6 to 4.8), were associated with larger ICU mortality.Higher GCS on admission (OR 0.81; 95% CI, 0.79 to 0.83), treatment with hydroxychloroquine (OR 0.78; 95% CI, 0.64 to 0.95) and tocilizumab (OR 0.58; 95% CI, 0.48 to 0.71) were inversely associated with ICU mortality.ConclusionThe SARS-CoV-2 critically ill Romanian patients share common personal and clinical characteristics with published European cohorts. Public health measures and vaccination campaign should focus on patients at risk.Copyright © 2022 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.

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