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Dtsch. Med. Wochenschr. · Nov 2022
[CAR-T cell therapy - personalized cellular immunotherapy in 2022].
- Janina Niebling, Wolfgang Bethge, and Claudia Lengerke.
- Dtsch. Med. Wochenschr. 2022 Nov 1; 147 (23): 155215641552-1564.
AbstractChimeric antigen receptor T cells (CAR T cells) are genetically modified autologous or allogeneic T lymphocytes that target specific antigens and can be used to combat tumor cells. The approval studies show a high response and remission rate in heavily pretreated patients with aggressive B-cell lymphoma, acute lymphoblastic leukemia or multiple myeloma. The article presents the indications for approval, the clinical implementation and the management of side effects of CAR cell therapy.Thieme. All rights reserved.
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