• Med. Clin. North Am. · Jan 2023

    Review

    The Role of Inflammation in the Pathophysiology of Depression and Suicidal Behavior: Implications for Treatment.

    • Gianluca Serafini, Alessandra Costanza, Andrea Aguglia, Andrea Amerio, Alice Trabucco, Andrea Escelsior, Leo Sher, and Mario Amore.
    • Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health DINOGMI, Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, Genoa 16132, Italy. Electronic address: gianluca.serafini@unige.it.
    • Med. Clin. North Am. 2023 Jan 1; 107 (1): 1291-29.

    AbstractDepression and suicidal behavior are 2 complex psychiatric conditions of significant public health concerns due to their debilitating nature. The need to enhance contemporary treatments and preventative approaches for these illnesses not only calls for distillation of current views on their pathogenesis but also provides an impetus for further elucidation of their novel etiological determinants. In this regard, inflammation has recently been recognized as a potentially important contributor to the development of depression and suicidal behavior. This review highlights key evidence that supports the presence of dysregulated neurometabolic and immunologic signaling and abnormal interaction with microbial species as putative etiological hallmarks of inflammation in depression as well as their contribution to the development of suicidal behavior. Furthermore, therapeutic insights addressing candidate mechanisms of pathological inflammation in these disorders are proposed.Copyright © 2022 Elsevier Inc. All rights reserved.

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