• Critical care clinics · Jan 2023

    Review

    Neuropharmacology in the Intensive Care Unit.

    • Abdalla Ammar, Mahmoud A Ammar, and Eljim P Tesoro.
    • Neurocritical Care, New York-Presbyterian/Weill Cornell Medical Center, 525 East 68th Street, New York City, NY 10065, USA.
    • Crit Care Clin. 2023 Jan 1; 39 (1): 171213171-213.

    AbstractClinicians must individualize pharmacotherapy for patients with acute neurological injury based on multiple factors, including age, comorbidities, and chronic medication use. Many pharmacokinetic and pharmacodynamic properties are altered during acute illness, particularly absorption, distribution, metabolism, and elimination, which may result in loss of drug effect or toxicity. This article provides clinicians with general pharmacologic knowledge of the following drug regimens commonly prescribed to neurocritically ill adults: sedatives, analgesics, osmotherapy, antiseizure medications, antishivering agents, vasoactive agents, and antithrombotic reversal agents.Copyright © 2022 Elsevier Inc. All rights reserved.

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