• Baoqing Geng, Keyue Zhang, Xianqian Huang, and Yong Chen.
• Department of Rheumatology and Immunology, Ningbo Huamei hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China.
• Clinics (Sao Paulo). 2022 Jan 1; 77: 100140100140.

ObjectiveThis study aimed to assess the correlation between Sjögren's Syndrome (SS) and adverse pregnancy outcomes, with the aim of providing a basis for preconception and pregnancy interventions in women with SS.MethodsA search of electronic databases in English and Chinese databases from January 2005 to December 2021, was conducted to collect the literature of case-control studies or cohort studies on the association between SS and pregnancy outcome studies. Literature inclusion and data extraction were performed according to established criteria, and the Newcastle-Ottawa scale was used to evaluate the quality of the literature. Stata 15 software was used for meta-analysis.ResultsA total of nine papers were included in this study. Meta-analysis results showed that SS was associated with spontaneous abortion (RR = 8.85, 95% CI 3.10‒25.26), preterm birth (RR = 2.27, 95% CI 1.46‒3.52), low birth mass (RR = 1.99, 95% CI 1.34‒2.97), and birth defects (RR = 4.28, 95% CI 3.08‒5.96).ConclusionSS can increase the incidence of adverse pregnancy outcomes.Copyright © 2022 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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