• Clinics · Jan 2022

    Clinical characteristics and evolution of 71 neonates born to mothers with COVID-19 at a tertiary center in Brazil.

    • Bruna de Paula Duarte, KrebsVera Lucia JornadaVLJDepartamento de Pediatria da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., Valdenise Martins Laurindo Tuma Calil, Werther Brunow de Carvalho, Maria Augusta Bento Cicaroni Gibelli, and FranciscoRossana Pulcineli VieiraRPVDepartamento de Ginecologia e Obstetrícia Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil..
    • Departamento de Pediatria da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address: brunadpduarte@gmail.com.
    • Clinics (Sao Paulo). 2022 Jan 1; 77: 100136100136.

    IntroductionLimited data are available on pregnant women with COVID-19 and their neonates.ObjectiveThis study aimed to describe clinical characteristics and evolution from birth to discharge of a retrospective cohort of 71 neonates, with one set of twins, born to women with COVID-19 diagnosed at the end of pregnancy. The authors included all newborns admitted into a neonatal unit of a tertiary hospital in Brazil, between March 2020 and March 2021, whose unvaccinated mothers had COVID-19 symptoms and RT-PCR (Real-Time Polymerase Chain Reaction) for SARS-CoV-2 positive within fourteen days prior to delivery. Newborns to mothers with COVID-19 symptoms and negative tests for SARS-CoV-2 were excluded.ResultsThe main route of birth delivery was cesarean, corresponding to 60 pregnant women (84.5%). The foremost indications for cesarean were pregnant with critical disease (24.6%) and acute fetal distress (20.3%). The mean birth weight was 2452 g (865‒3870 g) and the mean gestational age was 345/7 weeks (25‒40 weeks). There were 45 premature newborns (63.3%), of which 21 newborns (29.5%) were less than 32 weeks of gestational age. RT-PCR for SARS-CoV-2 on oropharyngeal swabs was positive in 2 newborns (2.8%) and negative in the other 69 newborns (97.2%). Most newborns (51.4%) needed respiratory support. Therapeutic interventions during hospitalization were inotropic drugs (9.9%), antibiotics (22.8%), parenteral nutrition (26.8%), and phototherapy (46.5%).ConclusionMaternal COVID-19 diagnosticated close to delivery has an impact on the first days of neonatal life.Copyright © 2022 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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