• Taha Şükrü Korkmaz, Tufan Agah Kartum, Gülçin Baş, Eren Fatma Akçıl, Rahşan Kemerdere, Seher Naz Yeni, and Taner Tanrıverdi.
• Department of Neurosurgery, Cerrahpaşa Medical Faculty, İstanbul University-Cerrahpaşa, İstanbul, Turkey.
• Turk J Med Sci. 2022 Oct 1; 52 (5): 164816551648-1655.

BackgroundTo assess the efficacy of postoperative antibiotics on postoperative infection in clean supratentorial craniotomies.MethodsThis study is a prospective, randomized, single-blind, and placebo-controlled clinical trial that included consecutive patients who underwent clean supratentorial craniotomy between November 2017 and September 2020 and evaluated the effectiveness of postoperative antibiotic prophylaxis on postoperative infection.ResultsA total of 80 patients were included and the whole group was divided into two groups. Group A included patients who received antibiotic prophylaxis and group B who did not receive antibiotic prophylaxis after surgery. Each group included the same number of patients (40 patients in each). Two patients showed postoperative infection, and both were in group B. No significant difference was found regarding postoperative infection between the two groups (p = 0.15). The rate of postoperative infection was found to be 2.5% in the whole group (2 cases out of 80) and it was 5% in group B (2 cases out of 40).DiscussionOur results showed that antibiotic prophylaxis after a clean supratentorial craniotomy has no effect on the prevention of postoperative infection and we do not suggest using antibiotic prophylaxis after clean supratentorial neurosurgery.

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