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- Michinori Ishitoku, Yusuke Yoshida, Toshiki Matsubara, Kenji Fujii, Ai Yorishima, Naoya Oka, Sho Masuda, Tomohiro Sugimoto, Sho Mokuda, Takao Masaki, and Shintaro Hirata.
- Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
- Intern. Med. 2023 Jul 1; 62 (13): 199920041999-2004.
AbstractA 72-year-old woman had a history of chronic hepatitis C virus (HCV) infection previously treated with interferon to achieve a sustained virologic response. Thereafter, she developed polyarthritis and purpura of the lower extremities as well as progressive renal dysfunction with hypertension and proteinuria that had occurred in the last three months. Laboratory investigations revealed seropositivity for cryoglobulin but negative findings for HCV RNA. She was ultimately diagnosed with cryoglobulinemic glomerulonephritis complicated by monoclonal gammopathy of undetermined significance (MGUS) based on the pathological findings of the kidney and bone marrow, indicating that MGUS-induced cryoglobulinemic vasculitis may occur even after HCV elimination.
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