• Giuliano De Carolis, Mery Paroli, Alessandro Dario, Emil Isagulyan, and Elizaveta Makashova.
• Anaesthesiology and Pain Therapy Unit Azienda, Ospedaliera Universitaria Pisana, Pisa, Italy. Electronic address: g.decarolis@ao-pisa.toscana.it.
• Neuromodulation. 2023 Apr 1; 26 (3): 650657650-657.

IntroductionThe aim of this case series was to assess the safety and effectiveness of peripheral nerve stimulation (PNS) of the brachial plexus performed using a low invasive percutaneous approach with ultrasound guide.Materials And MethodsPatients affected by neuropathic pain with a documented brachial plexus partial avulsion were included in this observational study. A totally implantable PNS system specifically designed for peripheral placement (Neurimpulse, Padua, Italy) was implanted and followed for 18 months, recording the level of pain (Numeric Rating Scale [NRS]), therapy satisfaction (Patient Global Impression of Improvement), quality of life (Short Form Health Survey questionnaire), and change in drug consumption and work status. Descriptive statistic (mean and SD) was used to compare pre- and postimplantation differences.ResultsA total of 18 patients were included in the observational study; 16 of them proceeded with the permanent implantation. System infection (N = 1) and lead migrations (N = 2) were recorded during a follow-up mean of 14.8 ± 5.4 months. The average NRS reduction at 18 months was 41%. Average quality-of-life physical and mental indexes increased by 14% and 32%, respectively. Drug intake was stopped in 22% and reduced in 56% of the patients.ConclusionsPNS systems of the brachial plexus implanted with percutaneous approach appear to be safe and effective in a follow-up period of 18 months. Longer and larger studies are needed to confirm and extend these outcomes.Published by Elsevier Inc.

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