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Case Reports
Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination.
- Masanobu Tanemoto, Ryosuke Oda, Yuichiro Toyama, Hirohiko Shizukawa, Kazuki Yokokawa, Taro Saito, Syuuichirou Suzuki, Akihiro Matsumura, and Shin Hisahara.
- Department of Neurology, Sapporo Medical University School of Medicine, Japan.
- Intern. Med. 2022 Dec 1; 61 (23): 360536093605-3609.
AbstractA 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, and a blood examination showed prominent elevation of creatinine kinase. Magnetic resonance imaging (MRI) revealed a high signal intensity in the thigh muscles on short-tau inversion recovery images, and antibody testing revealed positive findings for anti-signal recognition particle (SRP) antibody. Thus, anti-SRP antibody-positive immune-mediated myopathy was diagnosed. We initiated immunotherapy, and she was ultimately able to walk stably.
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