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Review Case Reports
A Case of Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review.
- Yoshiyuki Murawaki, Kazuo Yashima, Satoshi Horie, Masahiko Miura, Jun Kato, Takayuki Hirai, Kazuki Takeda, Michimori Kono, Manabu Yoshida, and Hajime Isomoto.
- Department of Gastroenterology, Matsue City Hospital, Japan.
- Intern. Med. 2023 Jul 15; 62 (14): 206320692063-2069.
AbstractA 46-year-old man was referred to our hospital for the examination of a flat elevated lesion with an erosion-like depression, located on the greater curvature of the antrum. Endoscopic submucosal dissection was performed. Histological findings of the resected specimen demonstrated a well-differentiated tubular adenocarcinoma with a diameter of 12 mm. No atrophy was observed in the tumor-adjacent mucosa. Serum Helicobacter pylori antibody estimation and 13C-urea breath tests yielded negative results. Immunohistochemical staining was positive for both gastric mucin and intestinal mucin. The final diagnosis was well-differentiated tubular adenocarcinoma with a gastrointestinal phenotype that originated in mucosa uninfected by H. pylori.
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