• Internal medicine · Jul 2023

    Case Reports

    Resolution of Laryngeal Ulceration with Prednisolone Therapy in a Patient with Crohn's Disease.

    • Yi-Ling Ko, Hiroki Matsuoka, Ryohei Nomaru, So Imakiire, Hideto Sakisaka, Satoshi Matsuoka, Nobuaki Kuno, Koichi Abe, Sadahiro Funakoshi, Yusuke Ishida, Hideki Ishibashi, Shinpei Miyagi, Toshifumi Sakata, and Fumihito Hirai.
    • Department of Gastroenterology and Medicine, Fukuoka University Hospital, Japan.
    • Intern. Med. 2023 Jul 15; 62 (14): 207120752071-2075.

    AbstractA 23-year-old man diagnosed with Crohn's disease (CD) was treated with infliximab. He developed new-onset sore throat and dysphagia during admission, and nasopharyngoscopy revealed epiglottic ulceration. Laryngeal ulceration was considered as an extraintestinal manifestation of CD owing to treatment failure with antibiotics and hydrocortisone. This strongly suggested that laryngeal ulceration was a complication of CD because of the rapid improvement in the symptoms and lesions after prednisolone administration. Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.

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