• William Nseir, Lior Masika, Adi Sharabi-Nov, and Raymond Farah.
• Department of Internal Medicine A, Padeh Medical Center, Poriya, Israel, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
• Isr Med Assoc J. 2022 Nov 1; 24 (11): 747751747-751.

BackgroundStatins have anti-inflammatory effects that are independent of their lipid-lowering activity.ObjectivesTo examine whether prior statins therapy affects the clinical course of the first episode of acute idiopathic pericarditis (AIP) as the 1-year recurrence and length of hospitalization (LOH).MethodsThis retrospective study included 148 subjects with first episode AIP admitted between the years 2015 and 2019. Data were collected from two hospitals in Northern Israel. We divided the patients in into two groups: 117 those without statins use and 31 those with prior statins use. We compared age, sex, co-morbidities, drugs, laboratory data, 1-year recurrence, and LOH.ResultsThe mean age of participants was 43.1 ± 19.4 years. Comparisons between subjects without statins and with prior statins use were made according to age (37.5 ± 16.7 years vs. 64.4 ± 12.7 years, P < 0.01), C-reactive protein (50 ± 40 vs. 48 ± 35 mg/dl, P = 0.9), LOH (5.4 ± 2.85 vs. 8.03 ± 4.92 days, P < 0.01), 1-year recurrence of pericarditis (23 vs. 6 cases, P = 0.95), respectively. Multivariate logistic regression analysis revealed that 1-year recurrence (odds ratio [OR] 0.8, 95% confidence interval [95%CI 0 0.6-1.1, P = 0.41), was not associated with prior statin use, while LOH (OR 2.56, 95%CI 2.08-2.75, P = 0.01) was prolonged with prior statins use in patients with first episode of AID.ConclusionsPrior statins use in patients with the first episode of AIP did not reduce the 1-year recurrence of pericarditis and prolong the LOH.

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