• Human genetics · Feb 1988

    Comparative Study

    Analysis of crossover type in the alpha -3.7 haplotype among sickle cell anemia patients from various parts of Africa.

    • C Dodé, A Berth, J Rochette, R Girot, and D Labie.
    • INSERM U.15, Institut de Pathologie Moléculaire, CHU Cochin-Port-Royal, Paris, France.
    • Hum. Genet. 1988 Feb 1;78(2):193-5.

    AbstractThe frequency of alpha+-thalassemia has been determined in African populations carrying beta S-chromosomes of different origins. All these alpha+ thalassemias result from a right-ward deletion. Restriction mapping of the alpha -3.7/haplotype with the enzyme ApaI only showed the presence of a type I crossover. RsaI polymorphism at the 5' end of Z alpha 2 is largely represented in the normal population (gene frequency 23%) but, in our series, never associated with the alpha -3.7/haplotype.

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