• Martín Ruiz-Ortiz, Carlos Sánchez-Fernández, José J Sánchez-Fernández, Leticia Mateos-de-la-Haba, Lucas Barreiro-Mesa, Cristina Ogayar-Luque, Elías Romo-Peñas, Mónica Delgado-Ortega, Ana Rodríguez-Almodóvar, Fátima Esteban-Martínez, José López-Aguilera, Francisco Carrasco-Ávalos, Juan C Castillo-Domínguez, Manuel Anguita-Sánchez, Manuel Pan, and Dolores Mesa-Rubio.
• Department of Cardiology, Reina Sofia University Hospital, Cordoba, Spain.
• J Womens Health (Larchmt). 2023 Jan 1; 32 (1): 637063-70.

AbstractBackground: Women and men with chronic coronary syndrome (CCS) have different clinical features and management, and studies on mid-term prognosis have reported conflicting results. Our objective was to investigate the impact of the female sex in the prognosis of the disease in the very long term. Methods and Results: We investigated differential features and very long-term prognosis in 1268 consecutive outpatients with CCS (337 [27%] women and 931 [73%] men). Women were older than men, more likely to have hypertension, diabetes, angina, and atrial fibrillation, and less likely to be exsmoker/active smoker and to have been treated with coronary revascularization (p < 0.05 for all). The prescription of statins, antiplatelets, and betablockers was similar in both groups. After up to 17 years of follow-up (median = 11 years, interquartile range = 4-15 years), cumulative incidences of acute myocardial infarction (10.2% vs. 11.8%) or stroke (11% vs. 10%) at median follow-up were similar, but the risks of major cardiovascular events (acute myocardial infarction, stroke, or cardiovascular death, 41.2% vs. 33.6%), hospital admission for heart failure (20.9% vs. 11.9%), or cardiovascular death (32.3% vs. 22.1%) were significantly higher for women (p < 0.0005), with a nonsignificant trend to higher overall mortality (45.2% vs. 39.1%, p = 0.07). However, after multivariate adjustment, all these differences disappeared. Conclusion: Although women and men with CCS presented a different clinical profile, and crude rates of major cardiovascular events, heart failure and cardiovascular death were higher in women, female sex was not an independent prognostic factor in this study with up to 17 years of follow-up.

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