• Enrico Giordan, Riccardo Radaelli, Paolo Gallinaro, Giulia Pastorello, Roberto Zanata, Giuseppe Canova, Elisabetta Marton, and Jacopo Del Verme.
• Neurosurgical Department, Aulss2 Marca Trevigiana, Treviso, Italy. Electronic address: enrico.giordan@aulss2.veneto.it.
• World Neurosurg. 2023 Mar 1; 171: e64e82e64-e82.

BackgroundFull-endoscopic spine surgery (FESS) indications already cover degenerative, infectious, and neoplastic diseases. This study aimed to use a bibliometric search and meta-analysis of the highest-quality studies in the last 20 years to determine the quantity and quality of FESS research, geographic distribution, and the outcomes for lumbar conditions.MethodsArticles on FESS published from 2000 to 2022 were screened and assessed through Web of Science, PubMed, and Scopus. Also, databases were searched for longitudinal studies to pool in a meta-analysis of patients undergoing FESS for lumbar conditions. After stratifying the risk of bias and having collected the studies of the highest quality, we included the proportion of patients with a satisfactory outcome and intraoperative and postoperative adverse events after the analysis of lumbar spine conditions.ResultsA total of 728 articles were identified by the bibliographic search. Between 2000 and 2021, the published articles increased 21-fold. Most were from China (70.15%), followed by South Korea (19.5%). Most were retrospective (68.3%) and regarding treatment of lumbar disease (86.4%). Fifty studies, including 34,828 patients, were pooled in the meta-analysis. More than 85% of patients experienced satisfactory improvement in each of different lumbar conditions. Major adverse events were <2%; recurrence and postoperative dysesthesia rates were within those reported for open or mini-invasive procedures.ConclusionsThis study may fill research gaps on FESS and lead to adequately designed studies. Our meta-analysis showed that FESS for lumbar diseases is a procedure with satisfactory outcomes and low rates of adverse events.Copyright © 2022 Elsevier Inc. All rights reserved.

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