• R Stammler, F Ackermann, M Vasse, A Verrat, A David, C Horodyckid, J Gratieux, I Marroun, M Groh, M Roumier, and R Paule.
• Department of internal medicine, national referral center for hyper eosinophilic syndrome, hôpital Foch, Suresnes, France.
• Rev Med Interne. 2022 Dec 1; 43 (12): 739742739-742.

IntroductionChlorpromazine is a commonly used drug in several medical conditions associated with a wide range of side effects. Few cases of hemostatic disorder have been reported in the literature.Case ReportA 39-year-old man had previously been diagnosed with a cavernous malformation of the medulla oblongata. Chlorpromazine was started to treat persistent hiccups. Twenty days later, the patient presented hepatitis and a pruritic rash. Haemostasis tests revealed a prolonged partial thromboplastin time associated with isolated decrease of factor VIII level and anti-factor VIII antibodies. Magnetic resonance imaging revealed recent asymptomatic bleeding. Introduction of eptacog alfa and prednisone allowed clinical and biological improvement as well as a prolonged remission after 12 months of follow-up.Copyright © 2022 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

15 keywords...

hide…