• Filiz Yarsilikal Guleroglu, Hatice Argun Atalmis, Icten Olgu Bafali, Gulser Bingol Dikdere, Irfan Dikdere, Murat Ekmez, Alpaslan Kaban, Fatma Karasabanoglu, Busra Seker Atas, Esra Selvi, Gulay Sumnu, Merve Topaktas, Merve Yasti Dayan, Sevilay Yavuz Dogu, and Ali Cetin.
• MD. Perinatologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey.
• Sao Paulo Med J. 2022 Jan 1; 141 (4): e2022323e2022323.

BackgroundCoronavirus disease 2019 (COVID-19) may be asymptomatic or symptomatic in pregnant women. Compared to non-pregnant reproductive-aged women, symptomatic individuals appear to have a higher risk of acquiring severe illness sequelae.ObjectivesWe assessed the clinical and laboratory characteristics and outcomes of pregnant COVID-19 patients unvaccinated for severe acute respiratory syndrome coronavirus 2 according to the trimester of pregnancy.Design And SettingThis was a retrospective observational study conducted in a tertiary-level hospital in Turkey.MethodsThis retrospective study reviewed the clinical and laboratory characteristics and outcomes of 445 pregnant COVID-19 patients hospitalized during the first, second, and third trimesters of pregnancy and 149 other pregnant women as controls in a tertiary center from April 2020 to December 2021. All participants were unvaccinated.ResultsOverall, the study groups were comparable in terms of baseline clinical pregnancy characteristics. There was no clear difference among the study participants with COVID-19 in the first, second, and third trimesters of pregnancy. However, a considerably high number of clinical and laboratory findings revealed differences that were consistent with the inflammatory nature of the disease.ConclusionsThe study results reveal the importance of careful follow-up of hospitalized cases as a necessary step by means of regular clinical and laboratory examinations in pregnant COVID-19 patients. With further studies, after implementing vaccination programs for COVID-19 in pregnant women, these data may help determine the impact of vaccination on the outcomes of pregnant COVID-19 patients.

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