• Felipe V C Machado, Claus F Vogelmeier, Rudolf A Jörres, Henrik Watz, Robert Bals, Tobias Welte, Martijn A Spruit, Peter Alter, and FranssenFrits M EFMEDepartment of Research and Development, Ciro, Horn, The Netherlands; Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Nether.
• Department of Research and Development, Ciro, Horn, The Netherlands; Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands; REVAL-Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Agoralaan Diepenbeek, Belgium. Electronic address: felipe.machado@uhasselt.be.
• Chest. 2023 May 1; 163 (5): 107110831071-1083.

BackgroundAlterations in body composition, including a low fat-free mass index (FFMI), are common in patients with COPD and occur regardless of body weight.Research QuestionIs the impact of low FFMI on exercise capacity, health-related quality of life (HRQL), and systemic inflammation different among patients with COPD stratified in different BMI classifications?Study Design And MethodsWe analyzed baseline data of patients with COPD from the COPD and Systemic Consequences-Comorbidities Network (COSYCONET) cohort. Assessments included lung function, bioelectrical impedance analysis, 6-min walk distance (6MWD), HRQL, and inflammatory markers. Patients were stratified in underweight, normal weight (NW), preobese, and obese according to BMI and as presenting low, normal, or high FFMI using 25th and 75th percentiles of reference values. Linear mixed models were used to investigate the associations between fat-free mass (FFM) and fat mass with secondary outcomes in each BMI group.ResultsTwo thousand one hundred thirty-seven patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stages 1-4; 61% men; mean ± SD age, 65 ± 8 years; mean ± SD FEV1, 52.5 ± 18.8% predicted) were included. The proportions of patients in underweight, NW, preobese, and obese groups were 12.3%, 31.3%, 39.6%, and 16.8%, respectively. The frequency of low FFMI decreased from lower to higher BMI groups (underweight, 81%; NW, 53%; preobese, 42%; and obese, 39%). FFM was associated with the 6MWD in the underweight group, even when adjusting for a broad set of covariates (P < .05). HRQL was not associated with FFM after adjustment for lung function or dyspnea (P > .32). Fat mass was associated with higher systemic inflammation in the NW and preobese groups (P < .05).InterpretationIn patients with COPD with lower weight, such as underweight patients, higher FFMI is associated independently with better exercise capacity. In contrast, in preobese and obese patients with COPD, a higher FFMI was not consistently associated with better outcomes.Copyright © 2022 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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