• Med. Clin. North Am. · Jan 2013

    Pancreas transplantation and reversal of diabetic nephropathy lesions.

    • Michael Mauer and Paola Fioretto.
    • Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55454, USA. mauer002@umn.edu
    • Med. Clin. North Am. 2013 Jan 1; 97 (1): 109114109-14.

    AbstractPancreas transplantation is the only available treatment that has restored long-term (10 or more years) normoglycemia without the risks of severe hypoglycemia, allowing testing of the reversibility of diabetic nephropathy lesions. The authors studied renal structure before and 5 and 10 years after pancreas transplantation in nonuremic patients with long-term type 1 diabetes, with established diabetic nephropathy lesions at baseline. Diabetic glomerular lesions were not significantly changed at 5 years but were dramatically improved after 10 years, with most patients' glomerular structure returning to normal at the 10-year follow-up. These studies also showed that tubulointerstitial remodeling was also possible.Copyright © 2013 Elsevier Inc. All rights reserved.

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