• Med. Clin. North Am. · Jul 2019

    Review

    Premenstrual Dysphoric Disorder.

    • Teresa Lanza di Scalea and Teri Pearlstein.
    • Assistant Professor of Psychiatry and Women's Health, Dell Medical School, University of Texas at Austin, Austin, TX, USA. Electronic address: teresa.lanza@austin.utexas.edu.
    • Med. Clin. North Am. 2019 Jul 1; 103 (4): 613628613-628.

    AbstractPremenstrual dysphoric disorder (PMDD) comprises emotional and physical symptoms and functional impairment that lie on the severe end of the continuum of premenstrual symptoms. Women with PMDD have a differential response to normal hormonal fluctuations. This susceptibility may involve the serotonin system, altered sensitivity of the GABAA receptor to the neurosteroid allopregnanalone, and altered brain circuitry involving emotional and cognitive functions. Serotonin reuptake inhibitors are considered the first-line treatment. Second-line treatments include oral contraceptives containing drospirenone, other ovulation suppression methods, calcium, chasteberry, and cognitive-behavioral therapy.Copyright © 2019 Elsevier Inc. All rights reserved.

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