• A M Sánchez-García, P Martínez-López, A M Gómez-González, J Rodriguez-Capitán, R J Jiménez-López, J M García Almeida, E Avanesi-Molina, N Zamboschi, C Rueda-Molina, V Doncel-Abad, A I Molina-Ramos, E Cabrera-César, I Ben-Abdellatif, M Gordillo-Resina, E Pérez-Mesa, M Nieto-González, P Nuevo-Ortega, C Reina-Artacho, P L Sánchez Fernández, M F Jiménez-Navarro, and M A Estecha-Foncea.
• Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Málaga, España.
• Med Intensiva. 2023 May 1; 47 (5): 257266257-266.

ObjectiveTo describe the sequelae one month after hospital discharge in patients who required admission to intensive care for severe COVID-19 pneumonia and to analyze the differences between those who received therapy exclusively with high-flow oxygen therapy compared to those who required invasive mechanical ventilation.DesignCohort, prospective and observational study.SettingPost-intensive care multidisciplinary program.Patients Or ParticipantsPatients who survived admission to the intensive care unit (ICU) for severe COVID-19 pneumonia from April 2020 to October 2021.InterventionsInclusion in the post-ICU multidisciplinary program.Main Variables Of InterestMotor, sensory, psychological/psychiatric, respiratory and nutritional sequelae after hospital admission.ResultsOne hundred and four patients were included. 48 patients received high-flow nasal oxygen therapy (ONAF) and 56 invasive mechanical ventilation (IMV). The main sequelae found were distal neuropathy (33.9% IMV vs. 10.4% ONAF); brachial plexopathy (10.7% IMV vs. 0% ONAF); decrease in grip strength: right hand 20.67 kg (± 8.27) in VMI vs. 31.8 kg (± 11.59) in ONAF and left hand 19.39 kg (± 8.45) in VMI vs. 30.26 kg (± 12.74) in ONAF; and limited muscle balance in the lower limbs (28.6% VMI vs. 8.6% ONAF). The differences observed between both groups did not reach statistical significance in the multivariable study.ConclusionsThe results obtained after the multivariate study suggest that there are no differences in the perceived physical sequelae one month after hospital discharge depending on the respiratory therapy used, whether it was high-flow nasal oxygen therapy or prolonged mechanical ventilation, although more studies are needed to be able to draw conclusions.© 2022 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

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