• Internal medicine · Jan 2008

    Comparative Study

    Long-term intensive insulin therapy for Japanese patients with type 2 diabetes mellitus.

    • Tomoya Umezono, Masao Toyoda, Makiko Abe, Keiko Kobayashi, Mayuko Kato, Masaaki Miyauchi, Takako Kobayashi, Naoyuki Yamamoto, Moritsugu Kimura, Mitsunori Yagame, and Daisuke Suzuki.
    • Internal Medicine, Division of Nephrology and Metabolism, Tokai University School of Medicine, Isehara. umechan@is.icc.u-tokai.ac.jp
    • Intern. Med. 2008 Jan 1; 47 (24): 210921152109-15.

    ObjectiveTo determine the clinical usefulness of long-term intensive insulin therapy in Japanese patients with type 2 diabetes.Patients And MethodsVarious clinical indicators and potential of withdrawal from insulin therapy were investigated in 20 type 2 diabetic patients receiving treatment in the outpatient clinic over a period of 8 years after starting intensive insulin therapy between April 1997 and March 1999.ResultsThe mean glycated hemoglobin (HbA1c) was approximately 6.5%, and there was no significant increase in insulin dose over a period of 8 years after commencement of intensive insulin therapy. Withdrawal from insulin therapy could be sustained in previously untreated patients.ConclusionOur results indicated the clinical usefulness of intensive insulin therapy over the long term in Japanese patients with type 2 diabetes and that such therapy could be especially useful for previously untreated patients.

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