• Internal medicine · Jan 2012

    Case Reports

    Long-term branched-chain amino acid supplementation improves glucose tolerance in patients with nonalcoholic steatohepatitis-related cirrhosis.

    • Teruki Miyake, Masanori Abe, Shinya Furukawa, Yoshio Tokumoto, Kumiko Toshimitsu, Teruhisa Ueda, Shin Yamamoto, Masashi Hirooka, Teru Kumagi, Yoichi Hiasa, Bunzo Matsuura, and Morikazu Onji.
    • Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan.
    • Intern. Med. 2012 Jan 1; 51 (16): 215121552151-5.

    AbstractBranched-chain amino acid (BCAA) supplements have mainly been administered as a nutritional intervention for decompensated liver cirrhosis. Several studies have shown that short-term BCAA supplementation improves insulin and glucose tolerance in patients with liver cirrhosis. However, the long-term effects of BCAA supplementation on glucose tolerance and in patients with nonalcoholic steatohepatitis (NASH)-related liver cirrhosis are unknown. Herein, we report 2 cases of NASH-related liver cirrhosis in which long-term BCAA supplementation improved glycemic control. We conclude that in the absence of an effective conventional therapy for NASH-related liver cirrhosis, BCAA supplementation should be considered as an alternative treatment.

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