• Internal medicine · Jan 2013

    Review Case Reports

    Dilated cardiomyopathy as a presenting feature of Cushing's syndrome.

    • Nobuyuki Shibusawa, Masanobu Yamada, Tetsu Hashida, Koshi Hashimoto, Tetsurou Satoh, Jun Horiguchi, Tetsunari Oyama, Izumi Takeyoshi, and Masatomo Mori.
    • Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan. nshibu@gunma-u.ac.jp
    • Intern. Med. 2013 Jan 1; 52 (10): 106710711067-71.

    AbstractCardiovascular complications, including cardiomegaly, myocardial ischemia and left ventricular hypertrophy, are some of the major determinants of the mortality rate in patients with Cushing's syndrome. We herein report the case of a patient with Cushing's syndrome caused by an adrenal adenoma who presented with congestive heart failure secondary to dilated cardiomyopathy. Follow-up echocardiography showed a marked improvement in the left ventricular cardiac function, and the plasma B-type natriuretic peptide (BNP) levels regressed after successful treatment. "Reversible" dilated cardiomyopathy is rarely associated with Cushing's syndrome; however, it should be recognized. Administering appropriate treatment in a timely manner can reverse this cardiomyopathy along with the other symptoms of Cushing's syndrome.

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