• Revista médica de Chile · Apr 2015

    [Amerindian admixture estimation based on serological and molecular methods].

    • Iván Pulgar-Alarcón, Macarena Fuentes-Guajardo, Elena Llop, and Francisco Rothhammer.
    • Rev Med Chil. 2015 Apr 1; 143 (4): 439443439-43.

    BackgroundAmerindian admixture is an important parameter to consider in epidemiological studies in American countries, to make a proper selection of cases and controls.AimTo compare Amerindian admixture estimates obtained using ABO*A and ABO*O blood group alleles and ancestral identity markers (AIMs) in the mixed Chilean population.Subjects And MethodsAmerindian admixture rates were determined in 720 Chilean volunteers residing in Arica and born in the 15 regions of the country, using ABO*O and ABO*A alleles and 40 AIMs selected from more than 500,000 single nucleotide polymorphisms (SNPs).ResultsMean admixture estimates obtained using ABO*O and ABO*A alleles and AIMs were 35, 47% and 48% respectively. There was concordance in estimates, with the exception of the admixture based on ABO*O allele and AIMs.ConclusionsIn Chile, Amerindian admixture estimates obtained using ABO*A could be used as an alternative to AIMs in justified cases provided the sample size is reasonably large.

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