• Satsuki Kawasaki, Haruo Misawa, Yasushi Tamura, Yoshinobu Kondo, Shinobu Satoh, Osamu Hasegawa, Satoshi Kato, and Yasuo Terauchi.
• Department of Endocrinology and Metabolism, Shonan Fujisawa Tokushukai Hospital, Japan.
• Intern. Med. 2013 Jan 1; 52 (22): 248324872483-7.

ObjectiveTo examine risk factors for coronary artery disease (CAD) and retinopathy in patients with type 2 diabetes mellitus (DM) and assess the relationship between CAD and retinopathy.MethodsA total of 1,003 outpatients with type 2 DM (578 men and 425 women) were classified into two groups according to the presence (based on ischemic findings on a resting electrocardiogram or a history of angina or myocardial infarction) or absence of CAD and four retinopathy stages based on the International Clinical Classification of Diabetic Retinopathy.ResultsStepwise multiple regression analyses showed that independent risk factors for CAD were age, the triglyceride (TG) level and smoking, while those for retinopathy included age, age of DM diagnosis, the HbA1c level and a female gender. The prevalence of CAD increased in association with the progression of retinopathy (p<0.01).ConclusionSince it is difficult to distinguish macrovascular and microvascular diseases, diabetic vascular disorders require comprehensive approaches to assessment and treatment.

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