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Randomized Controlled Trial Multicenter Study
A multicenter clinical trial of recombinant human GM-CSF hydrogel for the treatment of deep second-degree burns.
- Liping Zhang, Jiong Chen, and Chunmao Han.
- Department of Burn, The Second Affiliated Hospital, Zhejiang University College of Medicine, #88 Jiefang Road, Hangzhou, China.
- Wound Repair Regen. 2009 Sep 1;17(5):685-9.
AbstractWound healing is a complex and dynamic biological process. The efficacy and safety of a recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) hydrogel to promote deep-second-degree burn wound healing is evaluated in this study. In this multicenter, randomized, double-blind, and placebo-controlled clinical trial, 90 patients with deep second-degree burns were randomly assigned into two groups. Complete healing time and percentage of wound healing at different time points were observed and side effects were recorded. A statistically significant difference was noted at each time point (p<0.01). No side effects were observed. These results suggest that rhGM-CSF hydrogel can significantly accelerate deep second-degree burn wound healing and is considered to be safe.
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