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- A Kasuga, H Maruyama, T Sato, S Nogawa, H Mitamura, and T Saruta.
- Department of Internal Medicine, Keio University School of Medicine, Tokyo.
- Intern. Med. 1996 Jun 1; 35 (6): 512514512-4.
AbstractA case of cibenzoline-induced myasthenia-like syndrome is reported. A 67-year-old woman with renal failure and no previous disorder of neuromuscular junction complained of fatigue during climbing up a flight of stairs and experiencing heavy eyelids after administration of 100 mg/day of cibenzoline. Repetitive nerve stimulation tests revealed decrement at 5-10 Hz. After reduction of the dosage, myasthenia-like signs and symptoms disappeared. The peak cibenzoline concentration was still high even after the dose reduction (666.4 ng/ml). In conclusion, cibenzoline, at a high plasma level, may induce myasthenia-like syndrome without any disorder of the neuromuscular junction.
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