• Internal medicine · May 1997

    Review Case Reports

    A diabetic case with hemoglobin J-Meerut and low HbA1C levels.

    • M Yagame, K Jinde, D Suzuki, N Saotome, H Takano, R Tanabe, H Sato, K Kurokawa, H Sakai, M Matsumae, H Mase, and T Harano.
    • Department of Internal Medicine, Tokai University School of Medicine, Kanagawa.
    • Intern. Med. 1997 May 1; 36 (5): 351356351-6.

    AbstractA diabetic patient with hemoglobin (Hb) J-Meerut and low HbA1C levels is reported. An automatic glycohemoglobin analyzer used for the determination of HbA1C revealed an abnormal peak of the peripheral blood obtained from a Japanese female with diabetes. She showed a lower HbA1C level (3.7%) than expected from her fasting plasma glucose (172 mg/dl). High performance liquid chromatography and isoelectric focusing indicated that her abnormal hemoglobin was Hb J-Meerut [alpha 120(H3)Ala-->Glu] and it accounted for 28.3% of the total hemoglobin. Abnormal hemoglobinemia should be considered when a major discrepancy between the levels of HbA1C and fasting plasma glucose is observed.

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