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- K Hara, K Tobe, Y Uchigata, M Nakazono, K Yasuda, Y Terauchi, Y Iwamoto, Y Akanuma, S Kimura, and T Kadowaki.
- The Institute for Diabetes Care and Research, Asahi Life Foundation, Tokyo.
- Intern. Med. 2000 Feb 1; 39 (2): 143145143-5.
AbstractA 45-year-old Japanese man was referred to our hospital because of hyperglycemia despite the administration of as much as 120 U/day of human insulin. He had no history of injecting animal insulin. Free insulin was below 5 microU/ml, but a high titer of total insulin (about 3,000 microU/ml) was observed, suggesting the presence of antibodies against human insulin. Scatchard analysis showed an increased insulin binding capacity in the plasma characterized by a higher affinity for insulin. He was successfully treated by cessation of insulin administration. A Scatchard analysis series showed that a reduction in the insulin binding capacity of antibodies paralleled the improvement in glycemic control.
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