• A Tanaka, R Nishida, T Yoshida, M Koshikawa, M Goto, and T Kuwahara.
• Department of Nephrology, Osaka Saiseikai Nakatsu Hospital.
• Intern. Med. 2001 Apr 1; 40 (4): 296300296-300.

ObjectiveThe purpose of this article was to study and clarify the features of Chinese herb nephropathy (CHN) in Japan.Patients And MethodsThe subjects consisted of patients diagnosed as having CHN in Saiseikai Nakatsu Hospital and of those reported in the literature in Japan. We investigated the clinical and histological features of CHN patients in Japan and compared them with the Belgian cases.ResultsThe remarkable differences were as follows: (1) high prevalence in males compared with Belgian cases, (2) Fanconi syndrome was found in most cases, (3) no patients had malignant tumors in the urinary tract. In addition, the ascribed Chinese medicines in Japan were divided into three groups: 'Tenshin-toki-shigyaku-ka-gosyuyu-syokyo-to', 'Boui-ougi-to', and others.ConclusionCHN in Japan has some characteristics distinguished from Belgian nephropathy. One hypothesis is a susceptibility to aristolochic acids (AAs), which is considered to be a causative agent, may be different among races. Another is that there could be some other toxic substances affecting the clinical findings although they are not identified at present. Further studies must be undertaken to clarify these differences.

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