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Revista médica de Chile · Jan 1990
Comparative Study[The effect of anti-insulin antibodies and of peptide C residual secretion on the metabolic control of diabetes type 1].
- N Velasco, M Díaz de Valdés, A Arteaga, A M Acosta, M R Pellegrini, and A Foradori.
- Departamento Endocrinología, Metabolismo y Nutrición, Facultad de Medicina, Universidad Católica de Chile, Santiago.
- Rev Med Chil. 1990 Jan 1; 118 (1): 393-9.
AbstractIn 20 type I diabetic patients treated with conventional insulin preparations, we measured insulin antibodies and peptide C secretion. Peptide C levels 90 and 120 min after a standard breakfast correlated well with glucosylated Hb levels (r = -0.48 and -0.52, respectively). No correlation with free insulin levels was observed, in spite of a good correlation of the latter with blood glucose levels (r = -0.50 and -0.73, respectively). There was no relation between insulin antibody levels and peptide C or free insulin. Metabolic control was not affected by insulin antibodies. Insulin dose decreased in relation to the duration of the disease and reduction of body weight index and was not correlated to glycosylated Hb levels.
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