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Revista médica de Chile · May 1993
Comparative Study[HLA A, B, C and DR antigens in a urban population from Santiago of Chile].
- L Rodríguez, P Scagliotti, and T Quiroga.
- Unidad Docente Asociada de Laboratorio Clínico, Escuela de Medicina, P Universidad Católica de Chile, Santiago de Chile.
- Rev Med Chil. 1993 May 1; 121 (5): 523529523-9.
AbstractHLA antigens vary in different ethnical groups and in Chile there are no reports on the frequency of these antigens in a normal representative population. The few existing studies are of indigenous populations and control groups, without including HLA-DR antigens. Therefore, the aim of this study was to study the frequency of HLA A, B and C antigens in 349 individuals and HLA-DR in 257, using the microlymphocytotoxicity method, and compared the results with those on normal caucasian populations (Europe and USA). Significant differences were found for 7 antigens of group A, 10 of group B, 4 of group C and 6 of group DR. The observed difference allow us to conclude that the population from Santiago has a distinct HLA antigen distribution. This fact must be bore in mind future studies in genetics, paternity or autoimmune diseases.
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