• Medicina · Jan 2007

    Case Reports Comparative Study

    [Prevalence of antibodies to hantavirus among hemodialysis patients with end-stage renal failure in Kaunas and its district].

    • Arvydas Dargevicius, Rasa Petraityte, Birute Sribikiene, Elvyra Sileikiene, Loreta Razukeviciene, Edita Ziginskiene, Rita Vorobjoviene, Ausra Razanskiene, Kestutis Sasnauskas, Inga Arūne Bumblyte, and Vytautas Kuzminskis.
    • Department of Nephrology, Kaunas University of Medicine, Kaunas, Lithuania. arvydas.dargevicius@gmail.com
    • Medicina (Kaunas). 2007 Jan 1; 43 Suppl 1: 727672-6.

    UnlabelledThe objective of this study was to investigate the prevalence of antibodies to hantaviruses among hemodialysis patients with end-stage renal failure in Kaunas and its district.Material And MethodsSerums of 218 patients from four dialysis centers of Kaunas district were tested by using the immunoglobulin G antibody-capture enzyme-linked immunosorbent assay (ELISA). The reactivity of ELISA-positive sera was proven in Western blot tests using various hantavirus recombinant nucleocapsid proteins. The yeast-expressed nucleocapsid proteins were used for testing.ResultsAntibodies against Dobrava/Hantaan and Puumala hantaviruses were found in 16 patients (seroprevalence 7.4%). Most of the sera were positive for Dobrava hantavirus (81%). The ratio of males to females was 1.2:1. Seroprevalence was significantly higher in older patients.ConclusionsResults indicate that antibodies to two hantaviruses (Dobrava/Hantaan virus and Puumala virus) are prevalent among hemodialysis patients in Kaunas district with approximately the same seroprevalence as in neighboring countries.

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