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B Acad Nat Med Paris · Mar 2006
Review Comparative Study[Medical treatment of critical leg ischemia: current status and future perspectives of gene and cell therapy].
- Joseph Emmerich and Jean-Noël Fiessinger.
- Université Paris-Descartes, INSERM U765, Service de Médecine Vasculaire - HTA, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75908 Paris 15. joseph.emmerich@egp.aphp.fr
- B Acad Nat Med Paris. 2006 Mar 1; 190 (3): 667684667-80; discussion 680-1, 683-4.
AbstractCritical limb ischemia (CLI) is associated with a high risk of amputation and death. For patients who cannot be surgically revascularized, medical options include prostanoids, spinal cord stimulation and lumbar sympathectomy, but none of these treatments has a demonstrated impact on the amputation rate at six months. Gene and cell therapy, aimed at stimulating angiogenesis, have mainly been tested in phase I and II clinical trials. These approaches appear to be feasible and safe in the short-term, but large randomized studies are necessary to demonstrate their clinical benefits and long-term safety.
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