• Timothy L Jang, Trevor McKoy, Jonathan Hakim, and Hari M Polenakovik.
• Department of Internal Medicine, Wright State University, Dayton, OH, USA; Boonshoft School of Medicine, Wright State University, Dayton, OH, USA. Electronic address: timothy.jang@wright.edu.
• Am. J. Med. Sci. 2023 Mar 1; 365 (3): 294301294-301.

AbstractXanthogranulomatous pyelonephritis (XGP) is a rare variant of chronic pyelonephritis, occurring in the setting of obstructive uropathy and recurrent urinary tract infections (UTIs). It is difficult to diagnose as it can be asymptomatic until late-stage disease. Localized symptoms such as flank pain and dysuria may be attributed to nephrolithiasis or UTIs without prompting need for further workup. Extrarenal manifestations, most notably fistula formation, may present distal to the kidney and not be readily attributed to a renal pathology. The only known definitive therapy is nephrectomy. A delay in diagnosis can lead to fulminant complications or a more technically difficult nephrectomy. We present three cases of XGP, which serve to highlight the possibility of earlier diagnosis and resultant management options, including the potential for nephron-saving strategies. Early clinical and radiologic suspicion through awareness of risk factors may play an important role in preventing disease progression, avoiding late-stage complications, and improving treatment outcomes.Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

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