• Rachel Cooper, Gita D Mishra, and Diana Kuh.
• MRC Unit for Lifelong Health and Ageing, Division of Population Health, University College London, United Kingdom. r.cooper@nshd.mrc.ac.uk
• Am J Prev Med. 2011 Oct 1; 41 (4): 376384376-84.

BackgroundEvidence, mainly from cross-sectional studies, suggests that physical activity is a potentially important modifiable factor associated with physical performance and strength in older age. It is unclear whether the benefits of physical activity accumulate across life or whether there are sensitive periods when physical activity is more influential.PurposeTo examine the associations of leisure-time physical activity across adulthood with physical performance and strength in midlife, and to test whether there are cumulative benefits of physical activity.MethodsUsing data on approximately 2400 men and women from the UK Medical Research Council National Survey of Health and Development, followed up since birth in March 1946, the associations of physical activity levels during leisure time self-reported prospectively at ages 36, 43, and 53 years with grip strength, standing balance, and chair rise times, assessed by nurses at age 53 years (in 1999), were examined in 2010.ResultsThere were independent positive effects of physical activity at all three ages on chair rise performance, and at ages 43 and 53 years on standing balance performance, even after adjusting for covariates. These results were supported by evidence of cumulative effects found when using structured life course models. Physical activity and grip strength were not associated in women and, in men, only physical activity at age 53 years was associated with grip strength.ConclusionsThere are cumulative benefits of physical activity across adulthood on physical performance in midlife. Increased activity should be promoted early in adulthood to ensure the maintenance of physical performance in later life.Copyright © 2011 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

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