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B Acad Nat Med Paris · Oct 2010
Review[Tracheal allotransplantation after withdrawal of immunosuppressive therapy].
- Pierre Delaere, Jan Vrancks, Geert Verleden, Paul de Leyn, and Direk van Raemdonck.
- Otolaryngology and Head and Neck Surgery, University hospital Leuven - Belgique. Pierre.delaere@med.kuleuven.be
- B Acad Nat Med Paris. 2010 Oct 1; 194 (7): 133513371335-7; discussion 1337.
AbstractReconstruction of long-segment tracheal defects requires a vascularized allograft. We report successful tracheal allotransplantation after indirect revascularization of the graft in a heterotopic position. Immunosuppressive therapy was administered before the operation, and the tracheal allograft was wrapped in the recipient's forearm fascia. Once revascularization was achieved, the mucosal lining was replaced progressively with buccal mucosa from the recipient. At 4 months, the tracheal chimera was fully lined with mucosa, which consisted of respiratory epithelium from the donor and buccal mucosa from the recipient. After withdrawal of immunosuppressive therapy, the tracheal allograft was moved to its correct anatomical position with an intact blood supply. No treatment-limiting adverse effects occurred.
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