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- Y Arai, N Hirose, K Yamamura, M Nagai, H Jang, Y Hattori, and Y Ikeda.
- Department of Geriatric Medicine, Keio University School of Medicine, Tokyo, Japan. yasumich@tka.att.ne.jp
- Am. J. Med. Sci. 1999 Dec 1; 318 (6): 424427424-7.
AbstractGlutathione S-transferase (GST) M1 polymorphism is a marker for susceptibility to smoking-related neoplasms, such as lung and bladder cancer. Recently, a genetic deletion of GSTT1, an isoenzyme of GST, has been reported to be associated with myelodysplastic syndromes (MDS). A 59-year-old man with a long-term smoking habit was treated successfully for non-small-cell lung cancer. Four years after the surgical removal of his lung cancer, he developed MDS and died. Using a polymerase chain reaction-based genotyping method, he was found to have a deletion of both the GSTM1 and GSTT1 genes. Screening for the deletion of the GSTM1 and GSTT1 genes may be useful for assessing individual genetic susceptibility to smoking-related lung cancer and MDS.
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